Setting description

Taxel therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Niraparib
— param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
–+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
-+- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
-++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
+– param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
+-+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
++- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
+++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Niraparib
all param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
TP53- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
DRD+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 0 376 0
TP53- 4 360 0
TP53+ 1 359 2
DRD+ 1 167 1
TEfus+ 1 329 0
Hormone_therapies Taxel_therapies Niraparib
all 0.000 0.752 0.000
TP53- 0.008 0.720 0.000
TP53+ 0.002 0.718 0.004
DRD+ 0.002 0.334 0.002
TEfus+ 0.002 0.658 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 212 0 233
TP53- 361 2 370
TP53+ 325 7 334
DRD+ 185 4 314
TEfus+ 245 1 298
Hormone_therapies Taxel_therapies Niraparib
all 0.424 0.000 0.466
TP53- 0.722 0.004 0.740
TP53+ 0.650 0.014 0.668
DRD+ 0.370 0.008 0.628
TEfus+ 0.490 0.002 0.596
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 0 0 0
TP53- 27 65 23
TP53+ 8 23 2
DRD+ 0 0 0
TEfus+ 0 0 0
Hormone_therapies Taxel_therapies Niraparib
all 0.000 0.000 0.000
TP53- 0.054 0.130 0.046
TP53+ 0.016 0.046 0.004
DRD+ 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000


Errors & power

The overall error was 0.216.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies         Niraparib 
            0.014             0.204             0.006

The overall power was 0.752.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies         Niraparib 
            0.000             0.752             0.000

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Niraparib Taxel_therapies
all graduation 0 0 0 376
futility 0 212 233 0
max_n 0 0 0 0
n 634 (460, 744) 236 (116, 401) 224 (117, 388) 340 (176, 543)
n_unique 634 (460, 744) 236 (116, 401) 224 (117, 388) 340 (176, 543)
time_trial 60 (60, 60) 60 (29, 60) 60 (26, 60) 42 (22, 60)
time_stop NA (NA, NA) 39 (20, 55) 39 (20, 57) 36 (20, 54)
post_p NA (NA, NA) 0.02 (0, 0.17) 0.02 (0, 0.15) 1 (1, 1)
rate 0.017 (0.016, 0.018) 0.022 (0.019, 0.025) 0.022 (0.019, 0.025) 0.01 (0.009, 0.012)
DRD+ graduation 0 1 1 167
futility 0 185 314 4
max_n 0 0 0 0
n 164 (109, 205) 62 (32, 119) 73 (50, 131) 64 (31, 120)
n_unique 164 (109, 205) 62 (32, 119) 73 (50, 131) 64 (31, 120)
time_trial 60 (60, 60) 60 (37, 60) 45 (21, 60) 60 (36, 60)
time_stop NA (NA, NA) 43 (30, 55) 33 (19, 51) 43 (29, 57)
post_p NA (NA, NA) 0.12 (0.01, 0.5) 0.1 (0.01, 0.43) 0.99 (0.86, 1)
rate 0.017 (0.015, 0.02) 0.022 (0.017, 0.028) 0.022 (0.019, 0.027) 0.01 (0.008, 0.014)
TEfus+ graduation 0 1 0 329
futility 0 245 298 1
max_n 0 0 0 0
n 218 (146, 272) 82 (41, 162) 74 (47, 161) 108 (57, 189)
n_unique 218 (146, 272) 82 (41, 162) 74 (47, 161) 108 (57, 189)
time_trial 60 (60, 60) 60 (29, 60) 50 (24, 60) 48 (25, 60)
time_stop NA (NA, NA) 36 (26, 52) 34 (23, 55) 38 (23, 55)
post_p NA (NA, NA) 0.11 (0.01, 0.44) 0.09 (0, 0.4) 1 (0.94, 1)
rate 0.017 (0.015, 0.02) 0.022 (0.018, 0.027) 0.022 (0.019, 0.028) 0.01 (0.008, 0.013)
TP53- graduation 0 4 0 360
futility 0 361 370 2
max_n 0 27 23 65
n 347 (205, 423) 114 (53, 275) 101 (51, 257) 178 (84, 302)
n_unique 347 (205, 423) 114 (53, 275) 101 (51, 257) 178 (84, 302)
time_trial 60 (60, 60) 39 (20, 60) 37 (20, 60) 43 (22, 60)
time_stop NA (NA, NA) 32 (19, 52) 31 (19, 52) 36 (20, 53)
post_p NA (NA, NA) 0.05 (0, 0.37) 0.07 (0, 0.34) 1 (0.98, 1)
rate 0.017 (0.015, 0.019) 0.022 (0.019, 0.027) 0.022 (0.019, 0.027) 0.011 (0.009, 0.012)
TP53+ graduation 0 1 2 359
futility 0 325 334 7
max_n 0 8 2 23
n 299 (189, 352) 91 (50, 222) 88 (50, 207) 152 (79, 277)
n_unique 299 (189, 352) 91 (50, 222) 88 (50, 207) 152 (79, 277)
time_trial 60 (60, 60) 44 (25, 60) 45 (23, 60) 43 (22, 60)
time_stop NA (NA, NA) 35 (24, 51) 34 (21, 53) 35 (20, 54)
post_p NA (NA, NA) 0.07 (0, 0.37) 0.07 (0, 0.33) 1 (0.98, 1)
rate 0.017 (0.015, 0.019) 0.022 (0.018, 0.027) 0.022 (0.018, 0.027) 0.01 (0.009, 0.013)


By subgroup combinations:
subtype var Control Hormone_therapies Niraparib Taxel_therapies
— graduation 0 386 395 438
futility 0 0 0 0
max_n 0 27 23 46
n 198 (115, 247) 56 (23, 160) 44 (13, 155) 105 (51, 195)
n_unique 198 (115, 247) 56 (23, 160) 44 (13, 155) 105 (51, 195)
post_p NA (NA, NA) 0.13 (0.01, 0.5) 0.17 (0.01, 0.53) 1 (0.9, 1)
rate 0.017 (0.015, 0.02) 0.022 (0.018, 0.029) 0.022 (0.017, 0.031) 0.011 (0.009, 0.013)
–+ graduation 0 415 432 449
futility 0 0 0 0
max_n 0 27 21 42
n 52 (29, 73) 17 (6, 49) 14 (5, 48) 27 (13, 53)
n_unique 52 (29, 73) 17 (6, 49) 14 (5, 48) 27 (13, 53)
post_p NA (NA, NA) 0.28 (0.06, 0.65) 0.27 (0.07, 0.68) 0.91 (0.59, 0.99)
rate 0.017 (0.013, 0.022) 0.023 (0.015, 0.036) 0.023 (0.015, 0.039) 0.011 (0.007, 0.016)
-+- graduation 0 371 379 426
futility 0 0 0 0
max_n 0 8 2 22
n 134 (83, 161) 33 (12, 106) 30 (10, 101) 72 (34, 139)
n_unique 134 (83, 161) 33 (12, 106) 30 (10, 101) 72 (34, 139)
post_p NA (NA, NA) 0.15 (0.02, 0.54) 0.2 (0.02, 0.6) 0.99 (0.81, 1)
rate 0.017 (0.014, 0.02) 0.023 (0.018, 0.032) 0.022 (0.016, 0.033) 0.011 (0.008, 0.014)
-++ graduation 0 410 430 451
futility 0 0 0 0
max_n 0 8 2 21
n 87 (50, 115) 25 (9, 77) 20 (8, 70) 46 (23, 91)
n_unique 87 (50, 115) 25 (9, 77) 20 (8, 70) 46 (23, 91)
post_p NA (NA, NA) 0.25 (0.03, 0.62) 0.22 (0.03, 0.59) 0.96 (0.75, 1)
rate 0.017 (0.014, 0.021) 0.022 (0.016, 0.032) 0.023 (0.016, 0.036) 0.011 (0.007, 0.014)
+– graduation 0 416 436 445
futility 0 0 0 0
max_n 0 24 22 44
n 48 (26, 64) 16 (5, 43) 19 (10, 46) 18 (7, 40)
n_unique 48 (26, 64) 16 (5, 43) 19 (10, 46) 18 (7, 40)
post_p NA (NA, NA) 0.28 (0.06, 0.68) 0.24 (0.05, 0.65) 0.86 (0.5, 0.98)
rate 0.017 (0.013, 0.023) 0.022 (0.015, 0.038) 0.023 (0.016, 0.033) 0.01 (0.006, 0.017)
+-+ graduation 0 438 453 455
futility 0 0 0 0
max_n 0 24 20 40
n 43 (25, 62) 15 (5, 42) 17 (9, 45) 18 (6, 38)
n_unique 43 (25, 62) 15 (5, 42) 17 (9, 45) 18 (6, 38)
post_p NA (NA, NA) 0.29 (0.06, 0.7) 0.26 (0.04, 0.68) 0.86 (0.5, 0.98)
rate 0.017 (0.013, 0.023) 0.023 (0.014, 0.038) 0.023 (0.016, 0.035) 0.01 (0.006, 0.017)
++- graduation 0 402 428 431
futility 0 0 0 0
max_n 0 8 2 22
n 37 (22, 51) 13 (4, 34) 16 (7, 36) 13 (4, 32)
n_unique 37 (22, 51) 13 (4, 34) 16 (7, 36) 13 (4, 32)
post_p NA (NA, NA) 0.29 (0.08, 0.67) 0.28 (0.06, 0.66) 0.82 (0.41, 0.97)
rate 0.017 (0.012, 0.023) 0.023 (0.014, 0.039) 0.023 (0.015, 0.033) 0.01 (0.005, 0.018)
+++ graduation 0 433 454 455
futility 0 0 0 0
max_n 0 8 2 21
n 34 (20, 49) 13 (4, 35) 15 (7, 38) 12 (4, 30)
n_unique 34 (20, 49) 13 (4, 35) 15 (7, 38) 12 (4, 30)
post_p NA (NA, NA) 0.32 (0.07, 0.7) 0.3 (0.06, 0.67) 0.82 (0.48, 0.96)
rate 0.018 (0.012, 0.023) 0.023 (0.014, 0.038) 0.023 (0.015, 0.038) 0.01 (0.005, 0.019)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Taxel_therapies Hormone_therapies Niraparib
all count 376
time_stop 36 (20, 54)
n_trt 290 (170, 479)
n_control 428 (223, 622)
post_p 1 (0.98, 1)
order 2 (1, 3)
TP53- count 360 4
time_stop 36 (20, 53) 14 (12, 24)
n_trt 156 (80, 279) 62 (51, 104)
n_control 220 (123, 351) 80 (63, 123)
post_p 1 (0.94, 1) 0.9 (0.88, 0.94)
order 2 (1, 4) 1 (1, 1)
TP53+ count 359 1 2
time_stop 35 (21, 54) 39 (39, 39) 24 (22, 26)
n_trt 131 (79, 220) 94 (94, 94) 74 (69, 78)
n_control 178 (106, 276) 190 (190, 190) 116 (109, 124)
post_p 0.99 (0.93, 1) 0.92 (0.92, 0.92) 0.96 (0.95, 0.98)
order 2 (1, 4) 2 (2, 2) 1 (1, 1)
DRD+ count 167 1 1
time_stop 44 (29, 57) 30 (30, 30) 23 (23, 23)
n_trt 69 (52, 116) 59 (59, 59) 66 (66, 66)
n_control 134 (87, 180) 96 (96, 96) 76 (76, 76)
post_p 0.98 (0.95, 1) 0.98 (0.98, 0.98) 0.97 (0.97, 0.97)
order 4 (2, 5) 1 (1, 1) 1 (1, 1)
TEfus+ count 329 1
time_stop 38 (23, 55) 18 (18, 18)
n_trt 102 (61, 168) 50 (50, 50)
n_control 157 (91, 232) 72 (72, 72)
post_p 0.99 (0.95, 1) 0.95 (0.95, 0.95)
order 3 (1, 5) 1 (1, 1)
Futility:
signature var Hormone_therapies Niraparib Taxel_therapies
all count 212 233
time_stop 39 (20, 55) 39 (20, 57)
n_trt 160 (90, 294) 161 (92, 291)
n_control 432 (227, 617) 427 (233, 638)
post_p 0.01 (0, 0.1) 0.01 (0, 0.08)
order 5 (1, 8) 4 (1, 7)
TP53- count 361 370 2
time_stop 32 (19, 52) 31 (19, 52) 18 (16, 21)
n_trt 91 (54, 196) 88 (52, 190) 74 (61, 86)
n_control 204 (113, 342) 195 (109, 343) 108 (90, 127)
post_p 0.11 (0.02, 0.24) 0.09 (0.02, 0.22) 0.21 (0.21, 0.22)
order 3 (1, 6) 2 (1, 6) 1.5 (1.1, 1.9)
TP53+ count 325 334 7
time_stop 35 (23, 51) 34 (21, 53) 16 (14, 19)
n_trt 79 (52, 152) 80 (51, 172) 58 (51, 69)
n_control 183 (118, 279) 176 (102, 291) 75 (66, 95)
post_p 0.11 (0.02, 0.25) 0.09 (0.02, 0.24) 0.17 (0.08, 0.28)
order 3 (1, 6) 3 (1, 6.7) 1 (1, 1)
DRD+ count 185 314 4
time_stop 43 (31, 55) 33 (19, 51) 34 (27, 43)
n_trt 64 (50, 104) 66 (51, 107) 58 (52, 64)
n_control 135 (95, 178) 104 (60, 163) 116 (81, 148)
post_p 0.1 (0.02, 0.26) 0.1 (0.02, 0.23) 0.22 (0.21, 0.27)
order 5 (3, 8) 3 (1, 7) 3 (1.3, 4.7)
TEfus+ count 245 298 1
time_stop 36 (26, 53) 34 (23, 55) 20 (20, 20)
n_trt 72 (52, 126) 68 (51, 125) 55 (55, 55)
n_control 157 (106, 224) 146 (92, 229) 90 (90, 90)
post_p 0.12 (0.03, 0.24) 0.09 (0.02, 0.23) 0.27 (0.27, 0.27)
order 4 (2, 8) 4 (1, 7) 1 (1, 1)


By subgroup combinations

Graduation:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Taxel_therapies count 376 376 376 376 376 376 376 376
time 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54)
n 94 (48, 178) 25 (12, 48) 65 (33, 116) 41 (22, 76) 17 (6, 36) 15 (6, 34) 12 (4, 27) 10 (4, 25)
post_p 0.94 (0.67, 1) 0.8 (0.59, 0.97) 0.91 (0.62, 1) 0.87 (0.62, 0.99) 0.72 (0.57, 0.93) 0.71 (0.56, 0.94) 0.69 (0.57, 0.9) 0.69 (0.57, 0.9)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.005, 0.012) 0.009 (0.002, 0.014) 0.009 (0.005, 0.013) 0.009 (0.004, 0.013) 0.007 (0, 0.013) 0.008 (0, 0.014) 0.006 (0, 0.013) 0.007 (0, 0.015)
DRD+ Hormone_therapies count 1 1 1 1
time 30 (30, 30) 30 (30, 30) 30 (30, 30) 30 (30, 30)
n 10 (10, 10) 23 (23, 23) 13 (13, 13) 13 (13, 13)
post_p 0.61 (0.61, 0.61) 0.88 (0.88, 0.88) 0.71 (0.71, 0.71) 0.78 (0.78, 0.78)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.017 (0.017, 0.017) 0.004 (0.004, 0.004) 0.007 (0.007, 0.007) 0 (0, 0)
Niraparib count 1 1 1 1
time 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23)
n 16 (16, 16) 15 (15, 15) 14 (14, 14) 21 (21, 21)
post_p 0.76 (0.76, 0.76) 0.71 (0.71, 0.71) 0.82 (0.82, 0.82) 0.87 (0.87, 0.87)
r_prob 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.006 (0.006, 0.006) 0.014 (0.014, 0.014) 0.013 (0.013, 0.013) 0.007 (0.007, 0.007)
Taxel_therapies count 167 167 167 167
time 44 (29, 57) 44 (29, 57) 44 (29, 57) 44 (29, 57)
n 21 (12, 35) 22 (9, 35) 15 (6, 28) 16 (7, 27)
post_p 0.82 (0.71, 0.96) 0.78 (0.7, 0.96) 0.79 (0.66, 0.93) 0.77 (0.64, 0.94)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.007 (0.002, 0.012) 0.008 (0, 0.013) 0.006 (0, 0.012) 0.007 (0, 0.012)
TEfus+ Hormone_therapies count 1 1 1 1
time 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18)
n 4 (4, 4) 29 (29, 29) 9 (9, 9) 8 (8, 8)
post_p 0.6 (0.6, 0.6) 0.81 (0.81, 0.81) 0.66 (0.66, 0.66) 0.66 (0.66, 0.66)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 329 329 329 329
time 38 (23, 55) 38 (23, 55) 38 (23, 55) 38 (23, 55)
n 26 (14, 46) 43 (25, 77) 16 (6, 34) 12 (5, 27)
post_p 0.82 (0.72, 0.97) 0.88 (0.72, 0.99) 0.75 (0.64, 0.93) 0.75 (0.63, 0.92)
r_prob 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.008 (0.003, 0.013) 0.009 (0.004, 0.013) 0.007 (0, 0.013) 0.006 (0, 0.013)
TP53- Hormone_therapies count 4 4 4 4
time 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24)
n 43 (34, 61) 11 (6, 26) 6 (2, 7) 6 (4, 11)
post_p 0.76 (0.73, 0.78) 0.73 (0.63, 0.8) 0.66 (0.62, 0.74) 0.63 (0.61, 0.7)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.007 (0.005, 0.011) 0.003 (0, 0.009) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 360 360 360 360
time 36 (20, 53) 36 (20, 53) 36 (20, 53) 36 (20, 53)
n 92 (49, 172) 25 (13, 47) 18 (6, 36) 15 (6, 34)
post_p 0.95 (0.74, 1) 0.81 (0.71, 0.97) 0.75 (0.63, 0.92) 0.74 (0.63, 0.93)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.004, 0.012) 0.008 (0.002, 0.013) 0.006 (0, 0.012) 0.007 (0, 0.012)
TP53+ Hormone_therapies count 1 1 1 1
time 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39)
n 33 (33, 33) 32 (32, 32) 12 (12, 12) 17 (17, 17)
post_p 0.71 (0.71, 0.71) 0.73 (0.73, 0.73) 0.76 (0.76, 0.76) 0.82 (0.82, 0.82)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.01, 0.01) 0.015 (0.015, 0.015) 0.011 (0.011, 0.011) 0.012 (0.012, 0.012)
Niraparib count 2 2 2 2
time 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26)
n 18 (15, 22) 22 (20, 24) 20 (18, 21) 14 (9, 18)
post_p 0.76 (0.72, 0.81) 0.8 (0.75, 0.85) 0.75 (0.73, 0.77) 0.73 (0.68, 0.78)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.011 (0.01, 0.011) 0.003 (0.001, 0.006) 0.014 (0.013, 0.015) 0.002 (0, 0.004)
Taxel_therapies count 359 359 359 359
time 35 (21, 54) 35 (21, 54) 35 (21, 54) 35 (21, 54)
n 65 (34, 116) 41 (24, 74) 11 (4, 27) 10 (5, 26)
post_p 0.91 (0.74, 1) 0.86 (0.72, 0.98) 0.72 (0.62, 0.9) 0.72 (0.62, 0.9)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.005, 0.012) 0.009 (0.003, 0.013) 0.005 (0, 0.012) 0.006 (0, 0.013)
Futility:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Hormone_therapies count 212 212 212 212 212 212 212 212
time 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55)
n 42 (21, 111) 14 (5, 34) 24 (10, 69) 20 (6, 50) 13 (4, 30) 12 (4, 27) 9 (3, 24) 10 (3, 19)
post_p 0.2 (0.03, 0.43) 0.31 (0.1, 0.46) 0.24 (0.04, 0.44) 0.28 (0.06, 0.46) 0.31 (0.1, 0.48) 0.32 (0.12, 0.48) 0.34 (0.13, 0.48) 0.32 (0.09, 0.47)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.016, 0.03) 0.022 (0.014, 0.041) 0.022 (0.016, 0.036) 0.022 (0.015, 0.036) 0.022 (0.013, 0.042) 0.022 (0.013, 0.04) 0.022 (0.013, 0.046) 0.024 (0.013, 0.046)
Niraparib count 233 233 233 233 233 233 233 233
time 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57)
n 31 (12, 91) 11 (4, 31) 21 (6, 65) 16 (7, 45) 16 (9, 36) 16 (9, 32) 13 (7, 29) 13 (7, 30)
post_p 0.22 (0.05, 0.47) 0.3 (0.09, 0.47) 0.28 (0.06, 0.46) 0.28 (0.05, 0.47) 0.26 (0.07, 0.47) 0.3 (0.08, 0.48) 0.3 (0.07, 0.47) 0.32 (0.09, 0.46)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.015, 0.033) 0.024 (0.014, 0.042) 0.021 (0.015, 0.037) 0.022 (0.014, 0.036) 0.023 (0.015, 0.034) 0.022 (0.015, 0.036) 0.022 (0.015, 0.037) 0.023 (0.015, 0.038)
DRD+ Hormone_therapies count 185 185 185 185
time 43 (31, 55) 43 (31, 55) 43 (31, 55) 43 (31, 55)
n 20 (7, 40) 18 (6, 40) 14 (5, 28) 15 (5, 28)
post_p 0.31 (0.09, 0.48) 0.34 (0.1, 0.48) 0.32 (0.13, 0.47) 0.32 (0.08, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.014, 0.032) 0.021 (0.014, 0.034) 0.021 (0.014, 0.037) 0.023 (0.015, 0.039)
Niraparib count 314 314 314 314
time 33 (19, 51) 33 (19, 51) 33 (19, 51) 33 (19, 51)
n 18 (9, 36) 17 (10, 33) 15 (7, 29) 14 (7, 31)
post_p 0.33 (0.1, 0.48) 0.32 (0.09, 0.48) 0.36 (0.1, 0.48) 0.33 (0.11, 0.48)
r_prob 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.021 (0.013, 0.033) 0.021 (0.014, 0.034) 0.021 (0.013, 0.035) 0.022 (0.014, 0.038)
Taxel_therapies count 4 4 4 4
time 34 (27, 43) 34 (27, 43) 34 (27, 43) 34 (27, 43)
n 24 (15, 29) 14 (5, 26) 13 (7, 14) 7 (3, 14)
post_p 0.39 (0.38, 0.41) 0.34 (0.27, 0.42) 0.42 (0.38, 0.44) 0.44 (0.39, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.013 (0.011, 0.017) 0.025 (0.017, 0.039) 0.016 (0.013, 0.021) 0.024 (0.017, 0.041)
TEfus+ Hormone_therapies count 245 245 245 245
time 36 (26, 53) 36 (26, 53) 36 (26, 53) 36 (26, 53)
n 18 (7, 37) 26 (12, 61) 15 (6, 32) 12 (5, 26)
post_p 0.31 (0.12, 0.47) 0.31 (0.09, 0.47) 0.34 (0.11, 0.47) 0.35 (0.1, 0.48)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.015, 0.038) 0.02 (0.015, 0.029) 0.021 (0.013, 0.036) 0.022 (0.013, 0.045)
Niraparib count 298 298 298 298
time 34 (23, 55) 34 (23, 55) 34 (23, 55) 34 (23, 55)
n 13 (5, 33) 20 (8, 55) 17 (10, 34) 15 (8, 30)
post_p 0.31 (0.1, 0.48) 0.3 (0.07, 0.46) 0.31 (0.1, 0.48) 0.34 (0.1, 0.49)
r_prob 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.022 (0.014, 0.041) 0.02 (0.014, 0.036) 0.021 (0.014, 0.036) 0.022 (0.014, 0.036)
Taxel_therapies count 1 1 1 1
time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
n 20 (20, 20) 19 (19, 19) 8 (8, 8) 8 (8, 8)
post_p 0.48 (0.48, 0.48) 0.31 (0.31, 0.31) 0.41 (0.41, 0.41) 0.35 (0.35, 0.35)
r_prob 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.008 (0.008, 0.008) 0.015 (0.015, 0.015) 0.014 (0.014, 0.014) 0.014 (0.014, 0.014)
TP53- Hormone_therapies count 361 361 361 361
time 32 (19, 52) 32 (19, 52) 32 (19, 52) 32 (19, 52)
n 47 (23, 118) 15 (6, 37) 14 (5, 35) 13 (5, 33)
post_p 0.24 (0.04, 0.45) 0.33 (0.12, 0.47) 0.35 (0.14, 0.48) 0.35 (0.13, 0.48)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.015, 0.028) 0.021 (0.013, 0.039) 0.021 (0.012, 0.038) 0.021 (0.013, 0.039)
Niraparib count 370 370 370 370
time 31 (19, 52) 31 (19, 52) 31 (19, 52) 31 (19, 52)
n 37 (14, 108) 13 (5, 32) 17 (9, 37) 16 (9, 31)
post_p 0.3 (0.06, 0.48) 0.34 (0.12, 0.48) 0.32 (0.09, 0.48) 0.34 (0.1, 0.48)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.019 (0.013, 0.03) 0.021 (0.012, 0.042) 0.021 (0.013, 0.034) 0.021 (0.014, 0.035)
Taxel_therapies count 2 2 2 2
time 18 (16, 21) 18 (16, 21) 18 (16, 21) 18 (16, 21)
n 51 (37, 65) 8 (8, 9) 8 (7, 8) 6 (6, 7)
post_p 0.33 (0.26, 0.4) 0.34 (0.21, 0.46) 0.38 (0.35, 0.41) 0.41 (0.34, 0.48)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0)
rate 0.014 (0.01, 0.017) 0.025 (0.015, 0.036) 0.021 (0.021, 0.022) 0.02 (0.015, 0.024)
TP53+ Hormone_therapies count 325 325 325 325
time 35 (23, 51) 35 (23, 51) 35 (23, 51) 35 (23, 51)
n 30 (13, 71) 24 (10, 51) 11 (4, 26) 11 (4, 24)
post_p 0.27 (0.04, 0.47) 0.31 (0.09, 0.47) 0.36 (0.16, 0.48) 0.35 (0.13, 0.48)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.015, 0.032) 0.02 (0.014, 0.031) 0.021 (0.013, 0.045) 0.022 (0.013, 0.046)
Niraparib count 334 334 334 334
time 34 (21, 53) 34 (21, 53) 34 (21, 53) 34 (21, 53)
n 26 (10, 81) 19 (8, 55) 15 (8, 29) 14 (7, 31)
post_p 0.3 (0.06, 0.47) 0.31 (0.08, 0.47) 0.34 (0.11, 0.47) 0.37 (0.1, 0.49)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.013, 0.031) 0.021 (0.013, 0.037) 0.022 (0.014, 0.035) 0.021 (0.014, 0.039)
Taxel_therapies count 7 7 7 7
time 16 (14, 19) 16 (14, 19) 16 (14, 19) 16 (14, 19)
n 27 (25, 40) 19 (11, 26) 4 (3, 11) 3 (2, 6)
post_p 0.31 (0.27, 0.42) 0.44 (0.3, 0.48) 0.36 (0.22, 0.45) 0.3 (0.27, 0.41)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.019 (0.015, 0.021) 0.011 (0.007, 0.026) 0.029 (0.007, 0.074) 0.048 (0.016, 0.065)