Taxel therapies more effective in all the biomarker signatures
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| –+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| -+- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| -++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| +– | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| +-+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| ++- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| +++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| TP53- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 70.5, median = 57.5 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.8, hr = 0.46 | af = 1, hr = 1 |
|
|
|
|
|
|
The overall error was 0.216.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.014 0.204 0.006
The overall power was 0.752.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.000 0.752 0.000
| signature | var | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|
| all | graduation | 0 | 0 | 0 | 376 |
| futility | 0 | 212 | 233 | 0 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 634 (460, 744) | 236 (116, 401) | 224 (117, 388) | 340 (176, 543) | |
| n_unique | 634 (460, 744) | 236 (116, 401) | 224 (117, 388) | 340 (176, 543) | |
| time_trial | 60 (60, 60) | 60 (29, 60) | 60 (26, 60) | 42 (22, 60) | |
| time_stop | NA (NA, NA) | 39 (20, 55) | 39 (20, 57) | 36 (20, 54) | |
| post_p | NA (NA, NA) | 0.02 (0, 0.17) | 0.02 (0, 0.15) | 1 (1, 1) | |
| rate | 0.017 (0.016, 0.018) | 0.022 (0.019, 0.025) | 0.022 (0.019, 0.025) | 0.01 (0.009, 0.012) | |
| DRD+ | graduation | 0 | 1 | 1 | 167 |
| futility | 0 | 185 | 314 | 4 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 164 (109, 205) | 62 (32, 119) | 73 (50, 131) | 64 (31, 120) | |
| n_unique | 164 (109, 205) | 62 (32, 119) | 73 (50, 131) | 64 (31, 120) | |
| time_trial | 60 (60, 60) | 60 (37, 60) | 45 (21, 60) | 60 (36, 60) | |
| time_stop | NA (NA, NA) | 43 (30, 55) | 33 (19, 51) | 43 (29, 57) | |
| post_p | NA (NA, NA) | 0.12 (0.01, 0.5) | 0.1 (0.01, 0.43) | 0.99 (0.86, 1) | |
| rate | 0.017 (0.015, 0.02) | 0.022 (0.017, 0.028) | 0.022 (0.019, 0.027) | 0.01 (0.008, 0.014) | |
| TEfus+ | graduation | 0 | 1 | 0 | 329 |
| futility | 0 | 245 | 298 | 1 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 218 (146, 272) | 82 (41, 162) | 74 (47, 161) | 108 (57, 189) | |
| n_unique | 218 (146, 272) | 82 (41, 162) | 74 (47, 161) | 108 (57, 189) | |
| time_trial | 60 (60, 60) | 60 (29, 60) | 50 (24, 60) | 48 (25, 60) | |
| time_stop | NA (NA, NA) | 36 (26, 52) | 34 (23, 55) | 38 (23, 55) | |
| post_p | NA (NA, NA) | 0.11 (0.01, 0.44) | 0.09 (0, 0.4) | 1 (0.94, 1) | |
| rate | 0.017 (0.015, 0.02) | 0.022 (0.018, 0.027) | 0.022 (0.019, 0.028) | 0.01 (0.008, 0.013) | |
| TP53- | graduation | 0 | 4 | 0 | 360 |
| futility | 0 | 361 | 370 | 2 | |
| max_n | 0 | 27 | 23 | 65 | |
| n | 347 (205, 423) | 114 (53, 275) | 101 (51, 257) | 178 (84, 302) | |
| n_unique | 347 (205, 423) | 114 (53, 275) | 101 (51, 257) | 178 (84, 302) | |
| time_trial | 60 (60, 60) | 39 (20, 60) | 37 (20, 60) | 43 (22, 60) | |
| time_stop | NA (NA, NA) | 32 (19, 52) | 31 (19, 52) | 36 (20, 53) | |
| post_p | NA (NA, NA) | 0.05 (0, 0.37) | 0.07 (0, 0.34) | 1 (0.98, 1) | |
| rate | 0.017 (0.015, 0.019) | 0.022 (0.019, 0.027) | 0.022 (0.019, 0.027) | 0.011 (0.009, 0.012) | |
| TP53+ | graduation | 0 | 1 | 2 | 359 |
| futility | 0 | 325 | 334 | 7 | |
| max_n | 0 | 8 | 2 | 23 | |
| n | 299 (189, 352) | 91 (50, 222) | 88 (50, 207) | 152 (79, 277) | |
| n_unique | 299 (189, 352) | 91 (50, 222) | 88 (50, 207) | 152 (79, 277) | |
| time_trial | 60 (60, 60) | 44 (25, 60) | 45 (23, 60) | 43 (22, 60) | |
| time_stop | NA (NA, NA) | 35 (24, 51) | 34 (21, 53) | 35 (20, 54) | |
| post_p | NA (NA, NA) | 0.07 (0, 0.37) | 0.07 (0, 0.33) | 1 (0.98, 1) | |
| rate | 0.017 (0.015, 0.019) | 0.022 (0.018, 0.027) | 0.022 (0.018, 0.027) | 0.01 (0.009, 0.013) |
| subtype | var | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|
| — | graduation | 0 | 386 | 395 | 438 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 27 | 23 | 46 | |
| n | 198 (115, 247) | 56 (23, 160) | 44 (13, 155) | 105 (51, 195) | |
| n_unique | 198 (115, 247) | 56 (23, 160) | 44 (13, 155) | 105 (51, 195) | |
| post_p | NA (NA, NA) | 0.13 (0.01, 0.5) | 0.17 (0.01, 0.53) | 1 (0.9, 1) | |
| rate | 0.017 (0.015, 0.02) | 0.022 (0.018, 0.029) | 0.022 (0.017, 0.031) | 0.011 (0.009, 0.013) | |
| –+ | graduation | 0 | 415 | 432 | 449 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 27 | 21 | 42 | |
| n | 52 (29, 73) | 17 (6, 49) | 14 (5, 48) | 27 (13, 53) | |
| n_unique | 52 (29, 73) | 17 (6, 49) | 14 (5, 48) | 27 (13, 53) | |
| post_p | NA (NA, NA) | 0.28 (0.06, 0.65) | 0.27 (0.07, 0.68) | 0.91 (0.59, 0.99) | |
| rate | 0.017 (0.013, 0.022) | 0.023 (0.015, 0.036) | 0.023 (0.015, 0.039) | 0.011 (0.007, 0.016) | |
| -+- | graduation | 0 | 371 | 379 | 426 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 8 | 2 | 22 | |
| n | 134 (83, 161) | 33 (12, 106) | 30 (10, 101) | 72 (34, 139) | |
| n_unique | 134 (83, 161) | 33 (12, 106) | 30 (10, 101) | 72 (34, 139) | |
| post_p | NA (NA, NA) | 0.15 (0.02, 0.54) | 0.2 (0.02, 0.6) | 0.99 (0.81, 1) | |
| rate | 0.017 (0.014, 0.02) | 0.023 (0.018, 0.032) | 0.022 (0.016, 0.033) | 0.011 (0.008, 0.014) | |
| -++ | graduation | 0 | 410 | 430 | 451 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 8 | 2 | 21 | |
| n | 87 (50, 115) | 25 (9, 77) | 20 (8, 70) | 46 (23, 91) | |
| n_unique | 87 (50, 115) | 25 (9, 77) | 20 (8, 70) | 46 (23, 91) | |
| post_p | NA (NA, NA) | 0.25 (0.03, 0.62) | 0.22 (0.03, 0.59) | 0.96 (0.75, 1) | |
| rate | 0.017 (0.014, 0.021) | 0.022 (0.016, 0.032) | 0.023 (0.016, 0.036) | 0.011 (0.007, 0.014) | |
| +– | graduation | 0 | 416 | 436 | 445 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 24 | 22 | 44 | |
| n | 48 (26, 64) | 16 (5, 43) | 19 (10, 46) | 18 (7, 40) | |
| n_unique | 48 (26, 64) | 16 (5, 43) | 19 (10, 46) | 18 (7, 40) | |
| post_p | NA (NA, NA) | 0.28 (0.06, 0.68) | 0.24 (0.05, 0.65) | 0.86 (0.5, 0.98) | |
| rate | 0.017 (0.013, 0.023) | 0.022 (0.015, 0.038) | 0.023 (0.016, 0.033) | 0.01 (0.006, 0.017) | |
| +-+ | graduation | 0 | 438 | 453 | 455 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 24 | 20 | 40 | |
| n | 43 (25, 62) | 15 (5, 42) | 17 (9, 45) | 18 (6, 38) | |
| n_unique | 43 (25, 62) | 15 (5, 42) | 17 (9, 45) | 18 (6, 38) | |
| post_p | NA (NA, NA) | 0.29 (0.06, 0.7) | 0.26 (0.04, 0.68) | 0.86 (0.5, 0.98) | |
| rate | 0.017 (0.013, 0.023) | 0.023 (0.014, 0.038) | 0.023 (0.016, 0.035) | 0.01 (0.006, 0.017) | |
| ++- | graduation | 0 | 402 | 428 | 431 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 8 | 2 | 22 | |
| n | 37 (22, 51) | 13 (4, 34) | 16 (7, 36) | 13 (4, 32) | |
| n_unique | 37 (22, 51) | 13 (4, 34) | 16 (7, 36) | 13 (4, 32) | |
| post_p | NA (NA, NA) | 0.29 (0.08, 0.67) | 0.28 (0.06, 0.66) | 0.82 (0.41, 0.97) | |
| rate | 0.017 (0.012, 0.023) | 0.023 (0.014, 0.039) | 0.023 (0.015, 0.033) | 0.01 (0.005, 0.018) | |
| +++ | graduation | 0 | 433 | 454 | 455 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 8 | 2 | 21 | |
| n | 34 (20, 49) | 13 (4, 35) | 15 (7, 38) | 12 (4, 30) | |
| n_unique | 34 (20, 49) | 13 (4, 35) | 15 (7, 38) | 12 (4, 30) | |
| post_p | NA (NA, NA) | 0.32 (0.07, 0.7) | 0.3 (0.06, 0.67) | 0.82 (0.48, 0.96) | |
| rate | 0.018 (0.012, 0.023) | 0.023 (0.014, 0.038) | 0.023 (0.015, 0.038) | 0.01 (0.005, 0.019) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Taxel_therapies | Hormone_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 376 | ||
| time_stop | 36 (20, 54) | |||
| n_trt | 290 (170, 479) | |||
| n_control | 428 (223, 622) | |||
| post_p | 1 (0.98, 1) | |||
| order | 2 (1, 3) | |||
| TP53- | count | 360 | 4 | |
| time_stop | 36 (20, 53) | 14 (12, 24) | ||
| n_trt | 156 (80, 279) | 62 (51, 104) | ||
| n_control | 220 (123, 351) | 80 (63, 123) | ||
| post_p | 1 (0.94, 1) | 0.9 (0.88, 0.94) | ||
| order | 2 (1, 4) | 1 (1, 1) | ||
| TP53+ | count | 359 | 1 | 2 |
| time_stop | 35 (21, 54) | 39 (39, 39) | 24 (22, 26) | |
| n_trt | 131 (79, 220) | 94 (94, 94) | 74 (69, 78) | |
| n_control | 178 (106, 276) | 190 (190, 190) | 116 (109, 124) | |
| post_p | 0.99 (0.93, 1) | 0.92 (0.92, 0.92) | 0.96 (0.95, 0.98) | |
| order | 2 (1, 4) | 2 (2, 2) | 1 (1, 1) | |
| DRD+ | count | 167 | 1 | 1 |
| time_stop | 44 (29, 57) | 30 (30, 30) | 23 (23, 23) | |
| n_trt | 69 (52, 116) | 59 (59, 59) | 66 (66, 66) | |
| n_control | 134 (87, 180) | 96 (96, 96) | 76 (76, 76) | |
| post_p | 0.98 (0.95, 1) | 0.98 (0.98, 0.98) | 0.97 (0.97, 0.97) | |
| order | 4 (2, 5) | 1 (1, 1) | 1 (1, 1) | |
| TEfus+ | count | 329 | 1 | |
| time_stop | 38 (23, 55) | 18 (18, 18) | ||
| n_trt | 102 (61, 168) | 50 (50, 50) | ||
| n_control | 157 (91, 232) | 72 (72, 72) | ||
| post_p | 0.99 (0.95, 1) | 0.95 (0.95, 0.95) | ||
| order | 3 (1, 5) | 1 (1, 1) |
| signature | var | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|
| all | count | 212 | 233 | |
| time_stop | 39 (20, 55) | 39 (20, 57) | ||
| n_trt | 160 (90, 294) | 161 (92, 291) | ||
| n_control | 432 (227, 617) | 427 (233, 638) | ||
| post_p | 0.01 (0, 0.1) | 0.01 (0, 0.08) | ||
| order | 5 (1, 8) | 4 (1, 7) | ||
| TP53- | count | 361 | 370 | 2 |
| time_stop | 32 (19, 52) | 31 (19, 52) | 18 (16, 21) | |
| n_trt | 91 (54, 196) | 88 (52, 190) | 74 (61, 86) | |
| n_control | 204 (113, 342) | 195 (109, 343) | 108 (90, 127) | |
| post_p | 0.11 (0.02, 0.24) | 0.09 (0.02, 0.22) | 0.21 (0.21, 0.22) | |
| order | 3 (1, 6) | 2 (1, 6) | 1.5 (1.1, 1.9) | |
| TP53+ | count | 325 | 334 | 7 |
| time_stop | 35 (23, 51) | 34 (21, 53) | 16 (14, 19) | |
| n_trt | 79 (52, 152) | 80 (51, 172) | 58 (51, 69) | |
| n_control | 183 (118, 279) | 176 (102, 291) | 75 (66, 95) | |
| post_p | 0.11 (0.02, 0.25) | 0.09 (0.02, 0.24) | 0.17 (0.08, 0.28) | |
| order | 3 (1, 6) | 3 (1, 6.7) | 1 (1, 1) | |
| DRD+ | count | 185 | 314 | 4 |
| time_stop | 43 (31, 55) | 33 (19, 51) | 34 (27, 43) | |
| n_trt | 64 (50, 104) | 66 (51, 107) | 58 (52, 64) | |
| n_control | 135 (95, 178) | 104 (60, 163) | 116 (81, 148) | |
| post_p | 0.1 (0.02, 0.26) | 0.1 (0.02, 0.23) | 0.22 (0.21, 0.27) | |
| order | 5 (3, 8) | 3 (1, 7) | 3 (1.3, 4.7) | |
| TEfus+ | count | 245 | 298 | 1 |
| time_stop | 36 (26, 53) | 34 (23, 55) | 20 (20, 20) | |
| n_trt | 72 (52, 126) | 68 (51, 125) | 55 (55, 55) | |
| n_control | 157 (106, 224) | 146 (92, 229) | 90 (90, 90) | |
| post_p | 0.12 (0.03, 0.24) | 0.09 (0.02, 0.23) | 0.27 (0.27, 0.27) | |
| order | 4 (2, 8) | 4 (1, 7) | 1 (1, 1) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Taxel_therapies | count | 376 | 376 | 376 | 376 | 376 | 376 | 376 | 376 |
| time | 36 (20, 54) | 36 (20, 54) | 36 (20, 54) | 36 (20, 54) | 36 (20, 54) | 36 (20, 54) | 36 (20, 54) | 36 (20, 54) | ||
| n | 94 (48, 178) | 25 (12, 48) | 65 (33, 116) | 41 (22, 76) | 17 (6, 36) | 15 (6, 34) | 12 (4, 27) | 10 (4, 25) | ||
| post_p | 0.94 (0.67, 1) | 0.8 (0.59, 0.97) | 0.91 (0.62, 1) | 0.87 (0.62, 0.99) | 0.72 (0.57, 0.93) | 0.71 (0.56, 0.94) | 0.69 (0.57, 0.9) | 0.69 (0.57, 0.9) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.009 (0.005, 0.012) | 0.009 (0.002, 0.014) | 0.009 (0.005, 0.013) | 0.009 (0.004, 0.013) | 0.007 (0, 0.013) | 0.008 (0, 0.014) | 0.006 (0, 0.013) | 0.007 (0, 0.015) | ||
| DRD+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||
| time | 30 (30, 30) | 30 (30, 30) | 30 (30, 30) | 30 (30, 30) | ||||||
| n | 10 (10, 10) | 23 (23, 23) | 13 (13, 13) | 13 (13, 13) | ||||||
| post_p | 0.61 (0.61, 0.61) | 0.88 (0.88, 0.88) | 0.71 (0.71, 0.71) | 0.78 (0.78, 0.78) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.017 (0.017, 0.017) | 0.004 (0.004, 0.004) | 0.007 (0.007, 0.007) | 0 (0, 0) | ||||||
| Niraparib | count | 1 | 1 | 1 | 1 | |||||
| time | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | ||||||
| n | 16 (16, 16) | 15 (15, 15) | 14 (14, 14) | 21 (21, 21) | ||||||
| post_p | 0.76 (0.76, 0.76) | 0.71 (0.71, 0.71) | 0.82 (0.82, 0.82) | 0.87 (0.87, 0.87) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.006 (0.006, 0.006) | 0.014 (0.014, 0.014) | 0.013 (0.013, 0.013) | 0.007 (0.007, 0.007) | ||||||
| Taxel_therapies | count | 167 | 167 | 167 | 167 | |||||
| time | 44 (29, 57) | 44 (29, 57) | 44 (29, 57) | 44 (29, 57) | ||||||
| n | 21 (12, 35) | 22 (9, 35) | 15 (6, 28) | 16 (7, 27) | ||||||
| post_p | 0.82 (0.71, 0.96) | 0.78 (0.7, 0.96) | 0.79 (0.66, 0.93) | 0.77 (0.64, 0.94) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.007 (0.002, 0.012) | 0.008 (0, 0.013) | 0.006 (0, 0.012) | 0.007 (0, 0.012) | ||||||
| TEfus+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||
| time | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | 18 (18, 18) | ||||||
| n | 4 (4, 4) | 29 (29, 29) | 9 (9, 9) | 8 (8, 8) | ||||||
| post_p | 0.6 (0.6, 0.6) | 0.81 (0.81, 0.81) | 0.66 (0.66, 0.66) | 0.66 (0.66, 0.66) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| Taxel_therapies | count | 329 | 329 | 329 | 329 | |||||
| time | 38 (23, 55) | 38 (23, 55) | 38 (23, 55) | 38 (23, 55) | ||||||
| n | 26 (14, 46) | 43 (25, 77) | 16 (6, 34) | 12 (5, 27) | ||||||
| post_p | 0.82 (0.72, 0.97) | 0.88 (0.72, 0.99) | 0.75 (0.64, 0.93) | 0.75 (0.63, 0.92) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.008 (0.003, 0.013) | 0.009 (0.004, 0.013) | 0.007 (0, 0.013) | 0.006 (0, 0.013) | ||||||
| TP53- | Hormone_therapies | count | 4 | 4 | 4 | 4 | ||||
| time | 14 (12, 24) | 14 (12, 24) | 14 (12, 24) | 14 (12, 24) | ||||||
| n | 43 (34, 61) | 11 (6, 26) | 6 (2, 7) | 6 (4, 11) | ||||||
| post_p | 0.76 (0.73, 0.78) | 0.73 (0.63, 0.8) | 0.66 (0.62, 0.74) | 0.63 (0.61, 0.7) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.007 (0.005, 0.011) | 0.003 (0, 0.009) | 0 (0, 0) | 0 (0, 0) | ||||||
| Taxel_therapies | count | 360 | 360 | 360 | 360 | |||||
| time | 36 (20, 53) | 36 (20, 53) | 36 (20, 53) | 36 (20, 53) | ||||||
| n | 92 (49, 172) | 25 (13, 47) | 18 (6, 36) | 15 (6, 34) | ||||||
| post_p | 0.95 (0.74, 1) | 0.81 (0.71, 0.97) | 0.75 (0.63, 0.92) | 0.74 (0.63, 0.93) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.009 (0.004, 0.012) | 0.008 (0.002, 0.013) | 0.006 (0, 0.012) | 0.007 (0, 0.012) | ||||||
| TP53+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||
| time | 39 (39, 39) | 39 (39, 39) | 39 (39, 39) | 39 (39, 39) | ||||||
| n | 33 (33, 33) | 32 (32, 32) | 12 (12, 12) | 17 (17, 17) | ||||||
| post_p | 0.71 (0.71, 0.71) | 0.73 (0.73, 0.73) | 0.76 (0.76, 0.76) | 0.82 (0.82, 0.82) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.01 (0.01, 0.01) | 0.015 (0.015, 0.015) | 0.011 (0.011, 0.011) | 0.012 (0.012, 0.012) | ||||||
| Niraparib | count | 2 | 2 | 2 | 2 | |||||
| time | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | ||||||
| n | 18 (15, 22) | 22 (20, 24) | 20 (18, 21) | 14 (9, 18) | ||||||
| post_p | 0.76 (0.72, 0.81) | 0.8 (0.75, 0.85) | 0.75 (0.73, 0.77) | 0.73 (0.68, 0.78) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.011 (0.01, 0.011) | 0.003 (0.001, 0.006) | 0.014 (0.013, 0.015) | 0.002 (0, 0.004) | ||||||
| Taxel_therapies | count | 359 | 359 | 359 | 359 | |||||
| time | 35 (21, 54) | 35 (21, 54) | 35 (21, 54) | 35 (21, 54) | ||||||
| n | 65 (34, 116) | 41 (24, 74) | 11 (4, 27) | 10 (5, 26) | ||||||
| post_p | 0.91 (0.74, 1) | 0.86 (0.72, 0.98) | 0.72 (0.62, 0.9) | 0.72 (0.62, 0.9) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.009 (0.005, 0.012) | 0.009 (0.003, 0.013) | 0.005 (0, 0.012) | 0.006 (0, 0.013) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 212 | 212 | 212 | 212 | 212 | 212 | 212 | 212 |
| time | 39 (20, 55) | 39 (20, 55) | 39 (20, 55) | 39 (20, 55) | 39 (20, 55) | 39 (20, 55) | 39 (20, 55) | 39 (20, 55) | ||
| n | 42 (21, 111) | 14 (5, 34) | 24 (10, 69) | 20 (6, 50) | 13 (4, 30) | 12 (4, 27) | 9 (3, 24) | 10 (3, 19) | ||
| post_p | 0.2 (0.03, 0.43) | 0.31 (0.1, 0.46) | 0.24 (0.04, 0.44) | 0.28 (0.06, 0.46) | 0.31 (0.1, 0.48) | 0.32 (0.12, 0.48) | 0.34 (0.13, 0.48) | 0.32 (0.09, 0.47) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.021 (0.016, 0.03) | 0.022 (0.014, 0.041) | 0.022 (0.016, 0.036) | 0.022 (0.015, 0.036) | 0.022 (0.013, 0.042) | 0.022 (0.013, 0.04) | 0.022 (0.013, 0.046) | 0.024 (0.013, 0.046) | ||
| Niraparib | count | 233 | 233 | 233 | 233 | 233 | 233 | 233 | 233 | |
| time | 39 (20, 57) | 39 (20, 57) | 39 (20, 57) | 39 (20, 57) | 39 (20, 57) | 39 (20, 57) | 39 (20, 57) | 39 (20, 57) | ||
| n | 31 (12, 91) | 11 (4, 31) | 21 (6, 65) | 16 (7, 45) | 16 (9, 36) | 16 (9, 32) | 13 (7, 29) | 13 (7, 30) | ||
| post_p | 0.22 (0.05, 0.47) | 0.3 (0.09, 0.47) | 0.28 (0.06, 0.46) | 0.28 (0.05, 0.47) | 0.26 (0.07, 0.47) | 0.3 (0.08, 0.48) | 0.3 (0.07, 0.47) | 0.32 (0.09, 0.46) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.02 (0.015, 0.033) | 0.024 (0.014, 0.042) | 0.021 (0.015, 0.037) | 0.022 (0.014, 0.036) | 0.023 (0.015, 0.034) | 0.022 (0.015, 0.036) | 0.022 (0.015, 0.037) | 0.023 (0.015, 0.038) | ||
| DRD+ | Hormone_therapies | count | 185 | 185 | 185 | 185 | ||||
| time | 43 (31, 55) | 43 (31, 55) | 43 (31, 55) | 43 (31, 55) | ||||||
| n | 20 (7, 40) | 18 (6, 40) | 14 (5, 28) | 15 (5, 28) | ||||||
| post_p | 0.31 (0.09, 0.48) | 0.34 (0.1, 0.48) | 0.32 (0.13, 0.47) | 0.32 (0.08, 0.47) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.014, 0.032) | 0.021 (0.014, 0.034) | 0.021 (0.014, 0.037) | 0.023 (0.015, 0.039) | ||||||
| Niraparib | count | 314 | 314 | 314 | 314 | |||||
| time | 33 (19, 51) | 33 (19, 51) | 33 (19, 51) | 33 (19, 51) | ||||||
| n | 18 (9, 36) | 17 (10, 33) | 15 (7, 29) | 14 (7, 31) | ||||||
| post_p | 0.33 (0.1, 0.48) | 0.32 (0.09, 0.48) | 0.36 (0.1, 0.48) | 0.33 (0.11, 0.48) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.021 (0.013, 0.033) | 0.021 (0.014, 0.034) | 0.021 (0.013, 0.035) | 0.022 (0.014, 0.038) | ||||||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | |||||
| time | 34 (27, 43) | 34 (27, 43) | 34 (27, 43) | 34 (27, 43) | ||||||
| n | 24 (15, 29) | 14 (5, 26) | 13 (7, 14) | 7 (3, 14) | ||||||
| post_p | 0.39 (0.38, 0.41) | 0.34 (0.27, 0.42) | 0.42 (0.38, 0.44) | 0.44 (0.39, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.013 (0.011, 0.017) | 0.025 (0.017, 0.039) | 0.016 (0.013, 0.021) | 0.024 (0.017, 0.041) | ||||||
| TEfus+ | Hormone_therapies | count | 245 | 245 | 245 | 245 | ||||
| time | 36 (26, 53) | 36 (26, 53) | 36 (26, 53) | 36 (26, 53) | ||||||
| n | 18 (7, 37) | 26 (12, 61) | 15 (6, 32) | 12 (5, 26) | ||||||
| post_p | 0.31 (0.12, 0.47) | 0.31 (0.09, 0.47) | 0.34 (0.11, 0.47) | 0.35 (0.1, 0.48) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.015, 0.038) | 0.02 (0.015, 0.029) | 0.021 (0.013, 0.036) | 0.022 (0.013, 0.045) | ||||||
| Niraparib | count | 298 | 298 | 298 | 298 | |||||
| time | 34 (23, 55) | 34 (23, 55) | 34 (23, 55) | 34 (23, 55) | ||||||
| n | 13 (5, 33) | 20 (8, 55) | 17 (10, 34) | 15 (8, 30) | ||||||
| post_p | 0.31 (0.1, 0.48) | 0.3 (0.07, 0.46) | 0.31 (0.1, 0.48) | 0.34 (0.1, 0.49) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.022 (0.014, 0.041) | 0.02 (0.014, 0.036) | 0.021 (0.014, 0.036) | 0.022 (0.014, 0.036) | ||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | |||||
| time | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | ||||||
| n | 20 (20, 20) | 19 (19, 19) | 8 (8, 8) | 8 (8, 8) | ||||||
| post_p | 0.48 (0.48, 0.48) | 0.31 (0.31, 0.31) | 0.41 (0.41, 0.41) | 0.35 (0.35, 0.35) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.008 (0.008, 0.008) | 0.015 (0.015, 0.015) | 0.014 (0.014, 0.014) | 0.014 (0.014, 0.014) | ||||||
| TP53- | Hormone_therapies | count | 361 | 361 | 361 | 361 | ||||
| time | 32 (19, 52) | 32 (19, 52) | 32 (19, 52) | 32 (19, 52) | ||||||
| n | 47 (23, 118) | 15 (6, 37) | 14 (5, 35) | 13 (5, 33) | ||||||
| post_p | 0.24 (0.04, 0.45) | 0.33 (0.12, 0.47) | 0.35 (0.14, 0.48) | 0.35 (0.13, 0.48) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.02 (0.015, 0.028) | 0.021 (0.013, 0.039) | 0.021 (0.012, 0.038) | 0.021 (0.013, 0.039) | ||||||
| Niraparib | count | 370 | 370 | 370 | 370 | |||||
| time | 31 (19, 52) | 31 (19, 52) | 31 (19, 52) | 31 (19, 52) | ||||||
| n | 37 (14, 108) | 13 (5, 32) | 17 (9, 37) | 16 (9, 31) | ||||||
| post_p | 0.3 (0.06, 0.48) | 0.34 (0.12, 0.48) | 0.32 (0.09, 0.48) | 0.34 (0.1, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.019 (0.013, 0.03) | 0.021 (0.012, 0.042) | 0.021 (0.013, 0.034) | 0.021 (0.014, 0.035) | ||||||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | |||||
| time | 18 (16, 21) | 18 (16, 21) | 18 (16, 21) | 18 (16, 21) | ||||||
| n | 51 (37, 65) | 8 (8, 9) | 8 (7, 8) | 6 (6, 7) | ||||||
| post_p | 0.33 (0.26, 0.4) | 0.34 (0.21, 0.46) | 0.38 (0.35, 0.41) | 0.41 (0.34, 0.48) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.01, 0.017) | 0.025 (0.015, 0.036) | 0.021 (0.021, 0.022) | 0.02 (0.015, 0.024) | ||||||
| TP53+ | Hormone_therapies | count | 325 | 325 | 325 | 325 | ||||
| time | 35 (23, 51) | 35 (23, 51) | 35 (23, 51) | 35 (23, 51) | ||||||
| n | 30 (13, 71) | 24 (10, 51) | 11 (4, 26) | 11 (4, 24) | ||||||
| post_p | 0.27 (0.04, 0.47) | 0.31 (0.09, 0.47) | 0.36 (0.16, 0.48) | 0.35 (0.13, 0.48) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.02 (0.015, 0.032) | 0.02 (0.014, 0.031) | 0.021 (0.013, 0.045) | 0.022 (0.013, 0.046) | ||||||
| Niraparib | count | 334 | 334 | 334 | 334 | |||||
| time | 34 (21, 53) | 34 (21, 53) | 34 (21, 53) | 34 (21, 53) | ||||||
| n | 26 (10, 81) | 19 (8, 55) | 15 (8, 29) | 14 (7, 31) | ||||||
| post_p | 0.3 (0.06, 0.47) | 0.31 (0.08, 0.47) | 0.34 (0.11, 0.47) | 0.37 (0.1, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.02 (0.013, 0.031) | 0.021 (0.013, 0.037) | 0.022 (0.014, 0.035) | 0.021 (0.014, 0.039) | ||||||
| Taxel_therapies | count | 7 | 7 | 7 | 7 | |||||
| time | 16 (14, 19) | 16 (14, 19) | 16 (14, 19) | 16 (14, 19) | ||||||
| n | 27 (25, 40) | 19 (11, 26) | 4 (3, 11) | 3 (2, 6) | ||||||
| post_p | 0.31 (0.27, 0.42) | 0.44 (0.3, 0.48) | 0.36 (0.22, 0.45) | 0.3 (0.27, 0.41) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.019 (0.015, 0.021) | 0.011 (0.007, 0.026) | 0.029 (0.007, 0.074) | 0.048 (0.016, 0.065) |